Association between Adiponectin and Insulin Resistance among Sudanese Males with Type 2 Diabetes Mellitus
نویسندگان
چکیده
Background: Adiponectin is associated with improved systemic insulin sensitivity and profound positive effects in adipose tissue, such as increased mitochondrial density adipocytes, reducing adipocyte size, effective esterification of free fatty acids on lipid storage The factor performs forward transcriptional regulation. Diabetes its complications are considered to be one the main causes morbidity mortality worldwide. Aims objectives: aim this study was correlate serum levels adiponectin resistance Sudanese males' type 2 diabetes mellitus. Design Methods: A case-control community-based carried out among 126 patients T2DM cases group (mean ages 45.2±5.4 years); normal healthy individuals controls 44.7±5.4 years as) Aldaraga Diabetic Center, Wad Medani, Gezira State, Sudan. About Five mL fasting venous blood obtained from all participants. HbA1c, FPG, FPI, Adiponectin, (HOMA)- IR were analyzed. SPSS (v 20.0) used for data analysis. Results: mean (3.03±0.90µg/ml) lower than control (6.02±4.24µg/ml) giving highly significant differences -between them (P=value ≤ 0.000). HbA1c Homeostasis Model Assessment Insulin Resistance index (HOMA-IR) differed significantly between two groups (P-value Serum concentrations correlated negative HOMA (r = -0.149, P-value 0.002). Conclusion: We concluded that low plasma level predictive future development males.
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ژورنال
عنوان ژورنال: Chinese journal of medical research
سال: 2021
ISSN: ['2618-091X', '2663-8053']
DOI: https://doi.org/10.37515/cjmr.091x.4202